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What Are Apotex Eye Drops?

Apotex Inc., a global pharmaceutical company, produces several types of eye drops that each include specific ingredients for treating a variety of eye conditions. The company designed these ophthalmic solutions to be sterile medications safe for topical use in the eye.

Ophthalmic solutions available from Apotex include:
  • Brimonidine Tartrate: A medication that activates specific receptors (alpha-adrenergic receptors) in the eye to help prevent damage to the optic nerve and preserve vision
  • Ofloxacin: A type of quinolone antibiotic that kills the bacterial cells that cause infection
  • Olopatadine:A nonprescription medication effective on common allergens, including animal hair or dander, pollen, grass and ragweed

The U.S. Food and Drug Administration has said it will change eye drops and other ophthalmic medications regulated as drugs to drug-device combinations. Moving forward, such drugs and devices will have to comply with new requirements.

Use of Apotex Eye Drops

Apotex Inc. eye drops can help maintain overall eye health and function. The company’s ophthalmic solutions are formulated to manage a variety of symptoms related to eye pressure, infections or allergic reactions.

  • Allergic Conjunctivitis: Olopatadine can treat inflammation of the eye from an allergic reaction.
  • Bacterial Infections: Ofloxacin can treat bacterial infections of the eye, including pink eye, conjunctivitis and ulcers of the cornea.
  • Eye Pressure: Brimonidine tartrate can reduce pressure in the eyes for people with open-angle glaucoma or ocular hypertension.

Olopatadine is a type of mast cell stabilizer that prevents the release of histamines. It can also help suppress a type of white blood cell that causes inflammation and tissue damage. Ofloxacin doesn’t treat viral or fungal infections of the eyes but can kill bacteria such as types of Staphylococcus and harmful Enterobacter cloacae.

Brimonidine helps maintain a balance of fluid pressure inside the eye. An imbalance can lead to adverse outcomes including glaucoma, an inflammation of the eye’s middle layer (uveitis) and choroidal detachment (when the layer of blood vessels beneath the retina separates from the outer layer of the eye). This ophthalmic solution reduces the production of fluid inside the eye and increases drainage.

What Is the Correct Dosage for Apotex Eye Drops?

The dosage of Apotex eye drops depends on the condition needing treatment and the medication in use. Don’t wear contact lenses while applying these eye drops.

Dosages for Apotex Ophthalmic Solutions:
  • Brimonidine Tartrate: Apply one drop in the affected eyes three times daily, approximately eight hours apart.
  • Ofloxacin for Bacterial Corneal Ulcers: Apply one drop in the affected eye every 30 minutes during the day and one drop four-to-six hours after you go to bed, for two days. Step down to one drop every hour during the day for seven more days.
  • Ofloxacin for Conjunctivitis: Apply one drop in the affected eye every two-to-four hours during the day for two days. Step down to one drop in each eye four times a day for up to five more days.
  • Olopatadine Ophthalmic Solution: For the 0.1% solution, use one drop in each affected eye twice per day at an interval of six-to-eight hours. For the 0.2%/0.7% solution, use one drop in each affected eye once a day.

Be sure to follow specific instructions from your doctor, particularly when administering these medications to children. Tell your doctor about any other medications you’re taking. Some drugs may interact with Apotex eye drops. These include beta-blockers, high blood pressure medications, blood thinners, antidepressants and digoxin.

Apotex Eye Drop Side Effects

The most common side effects of Apotex eye drops are eye discomfort. These can include dry eyes, eye redness or watery eyes.

Side effects of Brimonidine Tartrate Ophthalmic Solution can include:
  • Cough
  • Difficulty falling asleep or staying asleep
  • Drowsiness
  • Dry eyes
  • Dry mouth
  • Eye itching
  • Eye pain
  • Eye redness
  • Flu-like symptoms
  • Headache
  • Heartburn
  • Pain or pressure in the face
  • Red or swollen eyelids
  • Runny nose and other cold symptoms
  • Sensitivity to light
  • Sore throat
  • Watery eyes
Less common but serious side effects of Ofloxacin Ophthalmic Solution have also been reported. Serious side effects may include:
  • Difficulty breathing or swallowing
  • Hives
  • Persistent eye itching
  • Skin rash
  • Swelling of the eyes, face and extremities
  • Vision changes

If you experience a serious side effect, you or your doctor can send a report to the FDA’s MedWatch Adverse Event Reporting program or via phone at 1-800-332-1088.

FDA Apotex Eye Drop Safety Warning

Apotex Inc. initiated a voluntary recall for consumers for six lots of Brimonidine Tartrate Ophthalmic Solution, 0.15%, on March 1, 2023. The Apotex eye drop recall was initiated because cracks developed in some bottles, which may have impacted sterility.

The Apotex recall is separate from other voluntary recalls of eye drops such as Global Pharma Healthcare, which voluntarily recalled its Artificial Tears Lubricant Eye Drops. EzriCare distributed the eye drops that were linked to three deaths as a result of contamination from antibiotic-resistant bacteria.
Pharmedica also recently recalled two lots of its Purely Soothing 15% MSM drops because of a risk of eye infections. There had been no reports of illness.

Please seek the advice of a qualified professional before making decisions about your health or finances.
Last Modified: October 4, 2023

17 Cited Research Articles

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  1. National Library of Medicine. (2023, April 4) Brimonidine Tartrate Ophthalmic Solution, 0.15% solution/drops. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a52b2033-0333-4630-9b1f-e22918b0962c
  2. Romero, T. (2023, March 8). Eyedrop brands recalled due to possible contamination issues. Retrieved from https://www.phillyvoice.com/eyedrops-recall-pharmedica-apotex/
  3. The Associated Press. (2023, March 8). 2 more eyedrop brands are recalled due to risks of injury and vision problems. Retrieved from https://www.npr.org/2023/03/08/1161876495/eyedrops-recalled-purely-soothing-pharmedica-apotex
  4. FDA. (2023, March 1). Apotex Corp. Issues Voluntary Nationwide Recall of Brimonidine Tartrate Ophthalmic Solution, 0.15% Due to Cracks that Have Developed in Some of the Units Caps of the Bottles. Retrieved from https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/apotex-corp-issues-voluntary-nationwide-recall-brimonidine-tartrate-ophthalmic-solution-015-due
  5. FDA. (2023, February 27). FDA warns consumers not to purchase or use EzriCare Artificial Tears due to potential contamination. Retrieved from https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-consumers-not-purchase-or-use-ezricare-artificial-tears-due-potential-contamination
  6. DailyMed. (2022, October 28) Ofloxacin Ophthalmic – Ofloxacin Solution. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fe564e33-8f5d-4b57-87a9-7afae02eaf97
  7. Machiele, R., Motlagh, M. & Patel, B. (2022, July 11). Intraocular Pressure. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK532237/
  8. Castronuovo, C. (2022, March 22). Eye Drops Will Be Regulated by FDA as Drug-Device Combinations. Retrieved from https://news.bloomberglaw.com/health-law-and-business/eye-drops-will-be-regulated-by-fda-as-drug-device-combinations
  9. DailyMed. (2022, February 3). Olopatadine – olopatadine hydrochloride solution/drops. Retrieved from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7de7f9ea-53e3-4f03-b60d-31a2817b5f49
  10. Apotex. (2021, December). Highlights of prescribing information. Retrieved from https://www.apotex.com/products/us/downloads/pre/brim_opso_ins.pdf
  11. Uchio, D. (2008, September). Treatment of allergic conjunctivitis with olopatadine hydrochloride eye drops. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694001/
  12. Cantor, L.B. (2006, December). Brimonidine in the treatment of glaucoma and ocular hypertension. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936355/
  13. Apotex. (n.d.) Olopatadine Ophthalmic Solution. Retrieved from https://www.apotex.com/products/us/detail.asp?m=53212
  14. Apotex (n.d.) Highlights of Prescribing Information. Retrieved from https://www.apotex.com/products/us/downloads/pre/olop_opso_0.2ins.pdf
  15. Lancaster General Health. (n.d.) ofloxacin ophthalmic. Retrieved from https://www.lancastergeneralhealth.org/healthwise-library/healthwise-article?documentId=d03977a1
  16. Apotex. (n.d.) Brimonidine Tartrate Ophthalmic Solution. Retrieved from https://www.apotex.com/products/us/detail.asp?m=46851
  17. Apotex (n.d.) Ofloxacin Ophthalmic Solution. Retrieved from https://www.apotex.com/products/us/detail.asp?m=44980